GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2243480 | 1 | rs6460260 | chr7:65215455 | CCT6P1 | chr7:65216092-65228661:+ | -0.32 | -4.49 | 9.5E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs6460261 | chr7:65215580 | CCT6P1 | chr7:65216092-65228661:+ | -0.32 | -4.49 | 9.5E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs6460274 | chr7:65628484 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.71 | 3.52E-6 | Diabetic kidney disease |
| BLCA | cis | rs11976180 | 1 | rs6464573 | chr7:143748098 | ARHGEF35 | chr7:143883677-143892736:- | 0.32 | 5.71 | 2.26E-8 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs6464574 | chr7:143748257 | ARHGEF35 | chr7:143883677-143892736:- | -0.36 | -6.38 | 5.22E-10 | Obesity-related traits |
| BLCA | cis | rs3091242 | 1 | rs646867 | chr1:25709258 | RHCE | chr1:25688741-25756683:- | 0.23 | 3.85 | 0.000139 | Erythrocyte sedimentation rate |
| BLCA | cis | rs3091242 | 1 | rs646867 | chr1:25709258 | RHD | chr1:25598981-25656935:+ | -0.49 | -8.44 | 6.76E-16 | Erythrocyte sedimentation rate |
| BLCA | cis | rs6474359 | 1 | rs6474359 | chr8:41549194 | AGPAT6 | chr8:41435707-41482520:+ | -0.48 | -4.75 | 2.83E-6 | Glycated hemoglobin levels |
| BLCA | cis | rs6474359 | 1 | rs6474359 | chr8:41549194 | AP3M2 | chr8:42010464-42028702:+ | -0.47 | -4.41 | 1.34E-5 | Glycated hemoglobin levels |
| BLCA | cis | rs6474359 | 1 | rs6474359 | chr8:41549194 | C8orf40 | chr8:42396298-42408139:+ | -0.46 | -4.3 | 2.19E-5 | Glycated hemoglobin levels |
| BLCA | cis | rs6474359 | 1 | rs6474359 | chr8:41549194 | GINS4 | chr8:41386725-41402563:+ | -0.45 | -4.97 | 1.02E-6 | Glycated hemoglobin levels |
| BLCA | cis | rs6474359 | 1 | rs6474359 | chr8:41549194 | GOLGA7 | chr8:41348081-41368497:+ | -0.61 | -5.28 | 2.2E-7 | Glycated hemoglobin levels |
| BLCA | cis | rs6474359 | 1 | rs6474359 | chr8:41549194 | MYST3 | chr8:41786998-41909505:- | -0.42 | -4.5 | 9.12E-6 | Glycated hemoglobin levels |
| BLCA | cis | rs6474359 | 1 | rs6474359 | chr8:41549194 | VDAC3 | chr8:42249346-42263413:+ | -0.45 | -3.95 | 9.36E-5 | Glycated hemoglobin levels |
| BLCA | cis | rs881375 | 1 | rs6478484 | chr9:123652380 | LOC253039 | chr9:123605320-123616644:+ | -0.35 | -5.97 | 5.46E-9 | Rheumatoid arthritis |